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KeyWords: Nigella sativa, black cumin, caraway, Kalonji, thymoquinone, Miracle herb, Ranunculaceae, Habat-ul-Sauda, Thymoquinone, Tibb-e-Nabwi, Black seeds, Anti-diabetic, Antioxidant, Black seeds, Anti-diabetic, Antioxidant, Central nervous system, Neuropharmacological effects, Anticoagulant, Antiviral, Chloroquine, SARS-CoV-2, RNA dependent RNA polymerase, Zinc transporter, Pneumocytes
Description and Abstracts:
KeyWords: Nigella sativa, black cumin, caraway, Kalonji, thymoquinone, Miracle herb, Ranunculaceae, Habat-ul-Sauda, Thymoquinone, Tibb-e-Nabwi, Black seeds, Anti-diabetic, Antioxidant, Black seeds, Anti-diabetic, Antioxidant, Central nervous system, Neuropharmacological effects, Anticoagulant, Antiviral, Chloroquine, SARS-CoV-2, RNA dependent RNA polymerase, Zinc transporter, Pneumocytes
Description and Abstracts:
Popular in various traditional systems of medicine like Unani and Tibb, Ayurveda and Siddha. Seeds and oil have a long history of folklore usage in various systems of medicines and food. Has been widely used as antihypertensive, liver tonics, diuretics, digestive, anti-diarrheal, appetite stimulant, analgesics, anti-bacterial and in skin disorders. Extensive studies on N. sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, renal protective, gastro-protective, antioxidant properties, etc. Due to its miraculous power of healing, N. sativa has got the place among the top ranked evidence based herbal medicines. Nigella sativa (black seed or black cumin), which belongs to the Ranunculacea family, is an annual herb with many pharmacological properties. Among its many active constituents, thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa (N. sativa) seeds, and it is the constituent to which most properties of this herb are attributed. In Islamic literature, it is considered as one of the greatest forms of healing medicine. It has been recommended for using on regular basis in Tibb-e-Nabwi (Prophetic Medicine). It has been widely used as antihypertensive, liver tonics, diuretics, digestive, anti-diarrheal, appetite stimulant, analgesics, anti-bacterial and in skin disorders. Extensive studies on N. sativa have been carried out by various researchers and a wide spectrum of its pharmacological actions have been explored which may include antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepato-protective, renal protective, gastro-protective, antioxidant properties, etc. Due to its miraculous power of healing, N. sativa has got the place among the top ranked evidence based herbal medicines. It has been widely used to treat nervous system diseases such as memory impairment, epilepsy, neurotoxicity, pain, etc. Additionally, this is uncovered that the majority of therapeutic properties of this plant are due to the presence of thymoquinone (TQ) which is a major bioactive component of the essential oil. Coronavirus disease-19 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Currently, the management of patients with COVID-19 depends mainly on repurposed drugs which include chloroquine, hydroxychloroquine, lopinavir/ritonavir, ribavirin, remdesivir, favipiravir, umifenovir, interferon-α, interferon-β and others. In this review, the potential of Nigella sativa (black cumin seeds) to treat the patients with COVID-19 analyzed, as it has shown to possess antiviral, antioxidant, anti-inflammatory, anticoagulant, immunomodulatory, bronchodilatory, antihistaminic, antitussive, antipyretic and analgesic activities. Various randomized controlled trials, pilot studies, case reports and in vitro and in vivo studies confirmed that N.sativa has antiviral, antioxidant, anti-inflammatory, immunomodulatory, bronchodilatory, antihistaminic, antitussive activities related to causative oraganism and signs and symptoms of COVID-19. N. sativa could be used as an adjuvant therapy along with repurposed conventional drugs to manage the patients with COVID-19. The SARS-CoV binds its spike (S) proteins to host angiotensin-converting enzyme 2 (ACE2). Following entry, the viral RNA is released in the cytoplasm – a potential site of thymoquinone to stop the release. In line with the proposed use of chloroquine, Nigella sativa (black seed) could be considered as a natural substitute that contains a number of bioactive components such as thymoquinone, dithymoquinone, thymohydroquinone, and nigellimine. Further benefits to use N. sativa could be augmented by Zn supplement. Notably, Zn has been proven to improve innate and adaptive immunity in the course of any infection, be it by pathogenic virus or bacteria. The effectiveness of the Zn salt supplement could also be enhanced with N. sativa as its major bioactive component might work as ionophore to allow Zn2+ to enter pneumocytes – the target cell for SARSCoV-2.PDF Source: 0101-2061-cta-1678-457X09516.pdf | Effect of black cumin oil (Nigella sativa L.) on fresh fish
PDF Source: 06-Hasnah-Haron.pdf | omparison of Physicochemical Analysis and Antioxidant Activities of Nigella sativa Seeds
PDF Source: 105868.pdf | Cultivar Influence on Total Polyphenol and Rutin Contents and Total Antioxidant Capacity
PDF Source: 13197_2017_Article_2853.pdf | Extraction, characterization and bioactive properties of Nigella sativa seedcake
PDF Source: 143840438.pdf | Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa)
PDF Source: 16-008.pdf | Nigella sativa (black seed) is an effective herbal remedy for every disease except death
PDF Source: 19-70.pdf | Effect of Dietary Black Cumin Seeds (Nigella Sativa L.) on the Performance of Broilers
PDF Source: 2042098616656812.pdf | Differential protection of black-seed oil on econucleotidase, cholinesterases
PDF Source: 2093-6966-v20-n01-029.pdf | Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced
PDF Source: 2093-6966-v20-n03-179.pdf | Clinical Trials of Black Seed (Nigella sativa and Its Active Constituent, Thymoquinone
PDF Source: 2093-6966-v23-n02-062.pdf | Prophetic Medicine-Nigella Sativa (Black Cumin Seeds Potential Herb for COVID-19
PDF Source: 35897-Article-Text-127507-1-10-20180306.pdf | Quantitative Determination of thymoquinone in Nigella Sativa and its nano formulation
PDF Source: 39_4_Cavar.pdf | Phenolic Compounds and Antioxidant Activity of Extracts of Nigella sativa L
PDF Source: 49-4-321.pdf | Nigella sativa Extract as a Potent Antioxidant for Petrochemical-Induced Oxidative Stress
PDF Source: 51255.pdf | Fatty Acids, Tocopherol, and Sterol Contents of Some Nigella Species Seed Oil
PDF Source: 5cdc363d4cd17ea7daa34bc4c4358d73772c.pdf | Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses
PDF Source: 7092514.pdf | Cosmeceutical and External Applications of Nigella sativa
PDF Source: 82397069.pdf | Dermatological effects of Nigella sativa
PDF Source: _20201012-swissmixit-pdf-search-library-methodology.pdf | SwissMixIt Methodology
PDF Source: Abdulghani-Topical-black-seed-011AA1.pdf | Topical Black Seed Oil Treatment of Allergic Rhinitis Anti-Inflammatory Anti-Allergy Agents
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PDF Source: AJHNM_DECEMBER_2018_Vol_30_No_4_RH.pdf | Herbal and Naturopathic Medicine 2018
PDF Source: AJP-6-009.pdf | Gastrointestinal effects of Nigella sativa and its main constituent, thymoquinone
PDF Source: AJP-6-034.pdf | Effects of Nigella sativa oil extract on inflammatory cytokine oxidative stress rheumatoid arthritis
PDF Source: AJP-6-124.pdf | Neuropharmacological effects of Nigella sativa
PDF Source: AJP-9-195.pdf | Clinical and experimental effects of Nigella sativa
PDF Source: ajptsp-20105257.pdf | Nigella Sativa L. Essential Oil-Loaded Solid Lipid Nanoparticles
PDF Source: Aminyoto_2018_IOP_Conf-Ser-A-Earth-Sci-144-012003.pdf | erection responses of Nigella sativa seed extract
PDF Source: Anti-Aging-Effect-Nigella-Sativa.pdf | Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging
PDF Source: antioxidants-08-00051.pdf | Antioxidant and Anti-Inflammatory Properties of Nigella sativa Oil in Human Pre-Adipocytes
PDF Source: apjtb-03-05-337.pdf | therapeutic potential of Nigella sativa: A miracle herb
PDF Source: benefits-Nigella-sativa-and-Zn-supplements-to-T-treat-COVID-19.pdf | Potential benefits of combination of Nigella sativa and Zn supplements treat COVID-19
PDF Source: BJBMS-17-286.pdf | phenolic profile, enzyme inhibitory and antimicrobial activities of Nigella sativa L. seed extracts
PDF Source: Black-Seed-Nigella-Sativa-Thymoquinone.pdf | Black Seed (Nigella Sativa) and its Constituent Thymoquinone Antidote against toxins
PDF Source: Black-Seed-Oil-as-an-Additive-to-Honey.pdf | BLACK SEED OIL AS AN ADDITIVE TO HONEY
PDF Source: black-seed-oil-cold-press-supplement-blood-pressure-heart-rate.pdf | Black Seed Oil Cold Press Supplement Over A Six Week Period on Blood Pressure and Heart Rate
PDF Source: Cosmeceutical_and_External_Application-black-seed.pdf | Cosmeceutical and External Applications of Nigella sativa black seed
PDF Source: Cosmetic_Product_Safety_Report.pdf | COSMETIC PRODUCT SAFETY REPORT Black Seed Oil
PDF Source: documentacceptedarticle.pdf | Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis
PDF Source: ECAM2016-6075679.pdf | Role of Nigella sativa and Its Active Constituents in Learning and Memory
PDF Source: ECAM2019-1528635.pdf | Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses
PDF Source: Effect-Of-Locally-Applied-Black-seed-Oil-And-Honey-Mixture-On-Wound-Healing.pdf | Effect of Locally Applied Black-seed Oil and Honey Mixture on Wound Healing
PDF Source: extracted-phenolics-black-cumin-Nigella-sativa.pdf | Characterization of extracted phenolics from black cumin (Nigella sativa linn
PDF Source: farahidah-binti-mohamed.pdf | ACADEMIC QUALIFICATION
PDF Source: hd-clear.pdf | Essential Oils Advanced Plant Technology Made by Nature
PDF Source: IJBMS-17-929.pdf | Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects
PDF Source: IJBMS-17-950.pdf | Thymoquinone: an emerging natural drug with a wide range of medical applications
PDF Source: IJBMS-17-967.pdf | Cardio-protective and anti-cancer therapeutic potential of Nigella sativa
PDF Source: IJBMS-21-1200.pdf | black cumin (Nigella sativa) and its active constituent, thymoquinone, in ischemia
PDF Source: ijerph-17-04160.pdf | Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing
PDF Source: IJPCR-Vol8-Issue11-Article13.pdf | Ethnomedicinal Plants: Study on the Chemical Composition and Antibacterial Activity of the Nigella sativa (Black Seed
PDF Source: ijpr-16-002.pdf | Black Seed (Nigella Sativa) Thymoquinone as an Antidote Protective Against Natural or Chemical Toxicities
PDF Source: JTM2017-7092514.pdf | Cosmeceutical and External Applications of Nigella sativa
PDF Source: MariodblackcuminFC09.pdf | Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa
PDF Source: medicinal_potential_of_black_seed_Nigella_sati.pdf | The medicinal potential of black seed (Nigella sativa
PDF Source: molecules-20-09560-1.pdf | Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L
PDF Source: molecules-20-09560.pdf | Comparative Studies on Polyphenolic, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin
PDF Source: NAPDD-555603.pdf | Black Seed (Nigella sativa) As Antimicrobial Drug
PDF Source: nigella-sativa-2246.pdf | Effect of Nigella sativa supplementation on human lipids
PDF Source: nigella-sativa-anti-cancer-properties.pdf | Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive
PDF Source: nigella-sativa-anti-tumor-6124.pdf | Anti-tumor effect of blackseed (Nigella sativa L) extracts
PDF Source: nigella-sativa-health-benefits-157.pdf | The Health Benefits of Black Seed (Nigella sativa
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PDF Source: nigella-sativa-kalonji-serum-lipid-profile.pdf | Effect of Nigella Sativa (Kalonji) on Serum Lipid Profile
PDF Source: nigella-sativa-lipid-profile-anti-oxidant.pdf | dietary supplementation with Nigella sativa L. on serum lipid profile
PDF Source: Nigella-sativa-Treat-Chemical-Wound.pdf | Nigella sativa Oil to Treat and Heal Chemical Induced Wound
PDF Source: Nigella_sativa_L_Black_Cumin_A_Promising_Natural.pdf | Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses
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PDF Source: PharmacognJ-10-99.pdf | Phytochemical Analysis of Nigella sativa L
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PDF Source: preparation-and-evaluation-of-topical-gel-of-nigella-sativa-kalonji-.pdf | PREPARATION AND EVALUATION OF TOPICAL GEL OF NIGELLA SATIVA (KALONJI
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PDF Source: PublishedManuscriptinJNSST.pdf | black Seed Nigella sativa Linnaeus: A Study of the Antioxidant Activity of the Essential Oil and Extracts
PDF Source: RDEN_Volume-10_Issue-1_Pages-151-157.pdf | Nigella Sativa Oil (Black Seed) on the Healing of Chemically Induced Oral Ulcer
PDF Source: Rusmarilin_2019_IOP-260-012097.pdf | antioxidants of black cumin seed (Nigella sativa
PDF Source: s12944-018-0704-x.pdf | Powdered black cumin seeds strongly improves serum lipids
PDF Source: Sahebkar-PharmacolRes2016.pdf | Nigella Sativa (Black Seed) Effects on Plasma Lipid Concentrations
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PDF Source: SudhirPublishedPaper_3-V7-Issue-8-August-2016-IJPSR-RE-18871.pdf | Nigella sativa seed, a novel beauty care ingredient
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