Flavonoid

Flavonoid : http://8swiss.com/flavonoid/index.htm

KeyWords: Flavonoids, Biological activity, polyphenols, phytochemicals, proanthocyanidins, functional foods, antioxidants, chemoprevention, apoptosis, inflammation, immune-regulation, tumor associated macrophages, medical foods, oxidative/nitrosative stress, Ca2, ATPases in aging and diseases, natural products, apigenin, dendritic cells, neuroinflammation, chronic inflammation, Coronaviruses, Positive-sense RNA viruses, COVID-19, SARS-CoV, SARS-CoV-2, MERS-CoV

Description and Abstracts:

KeyWords: Flavonoids, Biological activity, polyphenols, phytochemicals, proanthocyanidins, functional foods, antioxidants, chemoprevention, apoptosis, inflammation, immune-regulation, tumor associated macrophages, medical foods, oxidative/nitrosative stress, Ca2, ATPases in aging and diseases, natural products, apigenin, dendritic cells, neuroinflammation, chronic inflammation, Coronaviruses, Positive-sense RNA viruses, COVID-19, SARS-CoV, SARS-CoV-2, MERS-CoV

Description and Abstracts:

Flavonoids, a group of natural substances with variable phenolic structures, are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. These natural products are well known for their beneficial effects on health and efforts are being made to isolate the ingredients so called flavonoids. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. With more than 4000 compounds, flavonoids are the most abundant polyphenols present in plant foods.The major groups of flavonoids of nutritional interest are the flavanols, or catechins (e.g., epigallocatechin 3-gallate from green tea), the flavones (e.g., apigenin from celery), the flavonols (e.g., quercetin, ubiquitous in plant foods, particularly red onion and apple), the flavanones (e.g., naringenin from citrus), the anthocyanidins (e.g., cyanidin from berries), and the isoflavones (e.g., genistein and daidzein from soya beans). Once absorbed, flavonoids are mostly found as conjugates, with recent studies suggesting that tissue β-glucuronidase may release active aglycones from stable circulating glucuronides. Flavonoids are bioactive dietary constituents that may enhance health and help prevent chronic disease. The strongest evidence for chronic disease prevention is in the area of vascular health, where a meta-analysis revealed improvements in flow-mediated dilatation and blood pressure. Flavonoids are bioactive, polyphenolic, non-nutrients in plants, that are ubiquitous in diets. Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables, have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory, and estrogenic activities. Numerous cellular and animal-based studies show that flavonoids can function as antioxidants by preventing DNA damage and scavenging reactive oxygen radicals, inhibiting formation of DNA adducts, enhancing DNA repair, interfering with chemical damage by induction of Phase II enzymes, and modifying signaling pathways. Recent evidence also shows their ability to regulate the immune system. Flavonoids are widely distributed plant secondary metabolites with various metabolic functions. They are ubiquitous in fruits and vegetables that are regularly consumed by humans. These natural compounds are categorized by their chemical structure into 6 major subgroups as follows: chalcones, flavones, flavonols, flavandiols, anthocyanins, and proanthocyanidins or condensed tannins. Natural compounds with a great diversity of chemical structures may provide an alternative approach for the discovery of new antivirals. In fact, numerous flavonoids were found to have antiviral effects against SARS-and MERS-CoV by mainly inhibiting the enzymes 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids, flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants. Fruits, vegetables, plant-derived beverages such as green tea, wine and cocoa-based products are the main dietary sources of flavonoids. Flavonoids have been shown to possess a wide variety of anticancer effects: they modulate reactive oxygen species (ROS)-scavenging enzyme activities, participate in arresting the cell cycle, induce apoptosis, autophagy, and suppress cancer cell proliferation and invasiveness. Flavonoids have dual action regarding ROS homeostasis—they act as antioxidants under normal conditions and are potent pro-oxidants in cancer cells triggering the apoptotic pathways and downregulating pro-inflammatory signaling pathways. Fruits and vegetables, tea, and cocoa are rich natural sources of flavonoids. Epidemiological studies have indicated that consumption of these foods is likely to be associated with a reduced risk of cardiovascular disease. Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Phenolic acids and flavonoids also function as reducing agents, free radical scavengers, and quenchers of singlet oxygen formation. In addition, flavonoids and phenolic acids components play important roles in the control of cancer and other human diseases. For centuries, flavonoids and their preparations have been used to treat various human illnesses, and their continual use has persevered throughout the ages. This review focuses on the anti-inflammatory actions of flavonoids against chronic illnesses such as cancer, diabetes, cardiovascular diseases, and neuroinflammation with a special focus on apigenin, a relatively less toxic and non-mutagenic flavonoid with remarkable pharmacodynamics. Flavonoids occur in most plant species, and account for a significant percentage of the chemical constituents of some; e.g. dried green tea leaves contain approximately 30% flavonoids by weight.


PDF Source: 03_0442_tsk_ns.pdf | Optimization of flavonoids extraction from the leaves of Tabernaemontana heyneana Wall

PDF Source: 11101_2020_Article_9720.pdf | Flavonoids: A complementary approach to conventional therapy of COVID-19

PDF Source: 122_2009-CJFS.pdf | Extraction, Purification, and Characterisation of the Flavonoids from Opuntia milpa alta Skin

PDF Source: 12937_2017_Article_309.pdf | Dietary flavonoid intake in older adults: how many days of dietary assessment

PDF Source: 156899475.pdf | New phytochemicals as potential human anti-aging compounds

PDF Source: 1594689691670028714.pdf | Naringenin, a flavanone with antiviral and anti-inflammatory effects

PDF Source: 1934578×1200701103.pdf | Anti-Human Coronavirus (anti-HCoV) Triterpenoids from the Leaves of Euphorbia neriifolia

PDF Source: 1998norooziphd.pdf | Antioxidant effects of flavonoids

PDF Source: 20-255943.pdf | Identification of novel compounds against three targets of SARS CoV-2 coronavirus

PDF Source: 2008-b-flavonoids-as-components-of-biologically.pdf | Flavonoids as components of biologically active cosmeceuticals

PDF Source: 22608ccdf336b36c54eff6a4d6e8b9955a39.pdf | Structure degradation relationships of flavonoids and their correlation to human bioavailability

PDF Source: 2340-9894-ars-60-01-41.pdf | Preparation and physicochemical characterization of topical quercetin loaded liposome

PDF Source: 25213fa37eb59713313bd730792d51cffe25.pdf | Antioxidant properties of flavonoids

PDF Source: 404.pdf | Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms

PDF Source: 418.pdf | Flavonoids: a review of probable mechanisms of action and potential applications

PDF Source: 4485058-Malinowska.pdf | Effect of flavonoids content on antioxidant activity of commercial cosmetic plant extracts

PDF Source: 576.pdf | Flavonoids 4000 Compounds

PDF Source: 592035.pdf | Flavonoid-membrane interactions: A protective role

PDF Source: 613_pdf.pdf | Development of a Topical Formulation Containing S. Lutea Extract

PDF Source: _20201019-swissmixit-pdf-search-library-methodology.pdf | SwissMixIt Methodology

PDF Source: acs_0110.pdf | Lipophilization of flavonoids for their food, therapeutic and cosmetic applications

PDF Source: agronomy-10-01494-v2.pdf | Growth Nutrition Antioxidant in Peucedanum japonicum Thunb. under Various Plant Extracts

PDF Source: Antioxidant_properties_of_flavonoids.pdf | Antioxidant properties of flavonoids

PDF Source: antioxidants-03-00745.pdf | Antioxidant Flavonoids, Tannins and Phenolic Compounds in Psychotria Leaf Extracts

PDF Source: antioxidants-08-00035.pdf | Flavonoids in Treating Chronic Inflammatory Diseases Anti-Inflammatory Activity of Apigenin

PDF Source: antioxidants-08-00103.pdf | Flavonoids: New Frontier for Immuno-Regulation and Breast Cancer Contro

PDF Source: antioxidants-08-00202.pdf | Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease

PDF Source: antioxidants-09-00986-v2.pdf | Antioxidant and Anti-Inflammatory Activities in Relation to the Flavonoids Composition of Pepper

PDF Source: antioxidants-09-01003.pdf | Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules Phytochemical

PDF Source: antioxidants-09-01054.pdf | Electroactive Phenolic Contributors and Antioxidant Capacity

PDF Source: antioxidants-09-01067-v2.pdf | Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity

PDF Source: antioxidants-09-01113.pdf | Modulation of the Neuroprotective and Anti-inflammatory Activities of the Flavonol Fisetin

PDF Source: applsci-10-07981-v2.pdf | Quantitative Determination of Phenolic Acids and Flavonoids in Fresh Whole Crop Rice

PDF Source: aps20062.pdf | Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds

PDF Source: article1380724896_Ghasemzadeh and Ghasemzadeh.pdf | Flavonoids and phenolic acids: Role and biochemical activity in plants and human

PDF Source: b5db96ebc548a9388f5562a4dee8ad29c72d.pdf | ANTIAGING, ANTIOXIDANT FLAVONOIDS; SYNTHESIS, ANTIMICROBIAL SCREENING PREDICTION OF BIOLOGICAL ACTIVITY

PDF Source: biomedicines-08-00453-v2.pdf | Luteolin Induces Selective Cell Death of Human Pluripotent Stem Cells

PDF Source: Chen2018_Article_EffectOfFPZATotalFlavonoidsOin.pdf | FPZ flavonoids ointment topical application from Pouzolzia zeylanica var. microphylla, on mice skin infections

PDF Source: cosmetics-02-00259.pdf | Relevance of Natural Phenolics from Grape and Derivative Products in the Formulation of Cosmetics

PDF Source: cosmetics-07-00089.pdf | Flavonoids Taxonomic Data, History of Cosmetic Uses, Anti-Oxidant and Anti-Aging Potential of Alpinia galanga

PDF Source: cosmetics.pdf | Polyphenols as active ingredients for cosmetic products

PDF Source: covidsupplementonesheet.pdf | Supplements and COVID-19

PDF Source: diseases-05-00019.pdf | Flavonoids and Their Metabolites: Prevention in Cardiovascular Diseases and Diabetes

PDF Source: EJBR2017v7i2art108-123.pdf | Natural flavonoids: classification, potential role, and application of flavonoid analogues

PDF Source: ejcn2010221.pdf | Identification of the 100 richest dietary sources of polyphenols

PDF Source: Evaluation_of_anti-inflammatory_and_other_biologic.pdf | Evaluation of anti-inflammatory and other biological activities of flavonoid

PDF Source: Evaluation_of_Flavonoids_as_2019-nCoV_Cell_Entry_Inhibitor_Through_Molecular_Docking_and_Pharmacological_Analysis_v1.pdf | Evaluation of Flavonoids as 2019-nCoV Cell Entry Inhibitor Through Molecular Docking and Pharmacological Analysis

PDF Source: EXCLI-12-226.pdf | RECENT STUDIES ON FLAVONOIDS AND THEIR ANTIOXIDANT ACTIVITIES

PDF Source: extraction-phenolic-acide-flavonoids.pdf | Extraction, separation, and detection methods for phenolic acids and flavonoids

PDF Source: Extraction_isolation_and_identification_of_flavono.pdf | Extraction, isolation and identification of flavonoid from Euphorbia neriifolia leaves

PDF Source: flavonoid-antiviral-compounds.pdf | Antiviral and Electron-Shuttling Characteristics of Flavonoid Compounds for Antiviral Drug Development

PDF Source: flavonoidreview.pdf | Flavonoids and phenolic acids: Role and biochemical activity

PDF Source: flavonoids-complex-diets.pdf | Which Sources of Flavonoids: Complex Diets or Dietary Supplements

PDF Source: FLAVONOIDS-REVIEW-FOR-COSMETIC-APPLICATION-PART-TWO.pdf | FLAVONOIDS: A REVIEW FOR COSMETIC APPLICATION

PDF Source: Flavonoids-structure.pdf | Flavonoids: Their Structure, Biosynthesis and Role in the Rhizosphere, Including Allelopathy

PDF Source: Flavonoids.pdf | FLAVONOIDS POLYPHENOLS

PDF Source: Flavonoids_An_overview.pdf | Flavonoids: an overview 2016

PDF Source: Flavonoids_Anticancer_Properties.pdf | Flavonoids: Anticancer Properties

PDF Source: Flavonoids_as_Anticancer_Agents.pdf | Flavonoids as Anticancer Agents

PDF Source: foods-09-00430-v2.pdf | Composition, Phenols and Flavonoids Antioxidant Activity as Nutritive Potential of Roasted Hazelnut Skins

PDF Source: foods-09-01478-v2.pdf | Water-Based Extraction of Bioactive Principles from Blackcurrant Leaves and Chrysanthellum americanum: A Comparative Study

PDF Source: foods-09-01607.pdf | Microelements, Phenolics Antioxidant Activity in Wines from North-East Greec

PDF Source: ijms-14-03540.pdf | Flavonoids as Antioxidants and Developmental Regulators

PDF Source: IJPSR-2019-RE-27851.pdf | BIOLOGICAL ACTIVITIES OF FLAVONOIDS: AN OVERVIEW

PDF Source: ITX-4-114.pdf | Flavonoids in prevention of diseases with respect to modulation of Ca-pump function

PDF Source: LAJOP_26_5_1_6_UZB1B52YFH.pdf | Optimization of the Extraction of Flavonoids Compounds from Herbal Material

PDF Source: life-10-00223.pdf | Kenaf (Hibiscus cannabinus L.) Leaves and Seed as a Potential Source of the Bioactive Compounds

PDF Source: lung_injury_in_covid-19.pdf | Lung Injury in COVID-19

PDF Source: MillerAL-AntioxidantFlavonoids-AlternMedRev1996.pdf | Antioxidant flavonoids: Structure, function and clinical usage Article in Alternative medicine review

PDF Source: molecules-24-01182.pdf | Phenolic Compounds Extracted from the Bark of Woody Vascular Plants and Their Potential Biological Activity

PDF Source: molecules-25-04573.pdf | Flavonoid Profiles of Two New Approved Romanian Ocimum Hybrids

PDF Source: molecules-25-04590-v2.pdf | Aromadendrin Inhibits T Cell Activation via Regulation of Calcium Influx and NFAT Activity

PDF Source: molecules-25-04626-v2.pdf | Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

PDF Source: molecules-25-04746.pdf | Flavonoids and Their Disease Prevention and Treatment Potential

PDF Source: molecules-25-04756.pdf | Nanoencapsulation Using Homogenization on the Volatile Constituents and Anticancer and Antioxidant Activities

PDF Source: molecules-25-04763.pdf | Phytochemical Evaluation of Tinctures and Essential Oil Obtained from Satureja montana Herb

PDF Source: molecules-25-04870.pdf | Topical Wound Healing Activity of Myricetin Isolated from Tecomaria capensis v. aurea

PDF Source: molecules-25-04896.pdf | Crotalaria verrucosa Leaf Extract Mediated Synthesis of Zinc Oxide Nanoparticles

PDF Source: molecules-25-05033.pdf | Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma

PDF Source: molecules-25-05041.pdf | Water Extraction of Tannins from Aleppo Pine Bark and Sumac Root for the Production of Green Wood Adhesives

PDF Source: molecules-25-05060-v2.pdf | Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors

PDF Source: molecules-25-05112.pdf | Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation

PDF Source: molecules-25-05206.pdf | Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson’s Disease

PDF Source: molecules-25-05243.pdf | Important Flavonoids and Their Role as a Therapeutic Agent

PDF Source: nihms173012.pdf | Flavonoids and Age Related Disease: Risk, benefits and critical windows

PDF Source: NJONGMETA-DISSERTATION.pdf | EXTRACTABILITY PROFILING AND ANTIOXIDANT ACTIVITY OF FLAVONOIDS IN SORGHUM GRAIN AND NON-GRAIN MATERIALS

PDF Source: NQ58002.pdf | EFFECTS OFF LAVONOIDS AND OTHER PHYTOCHEMICALS ON FISH REPRODUCTIVE DEVELOPMENT

PDF Source: nutrients-02-01231.pdf | Chemistry and Biochemistry of Dietary Polyphenols

PDF Source: nutrients-09-01304.pdf | Elucidating the Skin Delivery of Aglycone and Glycoside Flavonoids: How the Structures Affect Cutaneous Absorption

PDF Source: nutrients-10-00438.pdf | Dietary Flavonoids in the Prevention of T2D: An Overview

PDF Source: nutrients-12-00457.pdf | Flavonoids as Anticancer Agents

PDF Source: nutrients-12-03297-v2.pdf | Associations between Intake of Dietary Flavonoids and 10-Year Incidence of Age-Related Hearing Loss

PDF Source: nutrients-12-03439-v2.pdf | Therapeutic Effects of Morinda citrifolia Linn. (Noni) Aqueous Fruit Extract on the Glucose and Lipid Metabolism

PDF Source: nuv008.pdf | Improving the estimation of flavonoid intake for study of health outcomes

PDF Source: P020200216630038723852.pdf | Potential Interventions for Novel Coronavirus in China

PDF Source: Pagesfromheijnen5.pdf | Protection of Flavonoids Against Lipid Peroxidation

PDF Source: pdf_MPJ_625.pdf | Anticancer, antioxidant properties and phenolic, flavonoid composition of Heracleum platytaenium

PDF Source: pharmaceutics-12-01053.pdf | Co-Microencapsulation of Flavonoids from Yellow Onion Skins and Lactic Acid Nutraceutical and Pharmaceutics

PDF Source: PharmacognJ-10-123.pdf | Phytochemical Screening, Total Flavonoid and Total Phenolic Content and Antioxidant Activity

PDF Source: PIIS0022202X15332255.pdf | Citrus Polymethoxy Flavonoid, Nobiletin Inhibits Sebum Production and Sebocyte Proliferation

PDF Source: plants-09-01344.pdf | LED Lights Promote Growth and Flavonoid Accumulation of Anoectochilus roxburghii

PDF Source: plants-09-01470-v3.pdf | Phytochemical Profiles, Antioxidant and Antibacterial Activities of Grape

PDF Source: Potential_of_Flavonoid-Inspired_Phytomedicines_aga.pdf | Potential of Flavonoid-Inspired Phytomedicines against COVID-19

PDF Source: PPIJ-08-00285.pdf | Flavonoids: A vital resource in healthcare and medicine

PDF Source: processes-08-00434.pdf | Conventional and Emerging Extraction Processes of Flavonoids

PDF Source: processes-08-00549-v2.pdf | Review of Evidence Available on Hesperidin-Rich Products vs COVID-19 and Hydrodynamic Cavitation-Based Extraction

PDF Source: processes-08-01218.pdf | Ultrasound-Assisted Extraction of Bioactive Compounds and Antioxidant Capacity for the Valorization

PDF Source: punica-granatum-extraction.pdf | Effect of extraction solvent on total phenol, total flavonoid content and antioxidant activities of extract

PDF Source: S1414.pdf | Can a Flavonoid, Quercetin, Be an Effective Topical Acne Medication

PDF Source: S2048679016000410a.pdf | Can a Flavonoid, Quercetin, Be an Effective Topical Acne Medication

PDF Source: the-science-of-flavonoids.pdf | The Science of Flavonoids

PDF Source: The_Anti-Aging_Potential_of_Neohesperidin_and_Its_.pdf | Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids

PDF Source: Theinfluenceofflavonoidsontheskincolour.pdf | The influence of Flavonoids on the Skin Colour

PDF Source: thesis-flavone.pdf | Flavone: the Molecular and Mechanistic Study of How a Simple Flavonoid Protects DNA from Oxidative Damage

PDF Source: thesis-flavonoids-conjugates.pdf | Trace-level determination of flavonoids and their conjugates

PDF Source: thesis-salvia-absconditiflora-extract.pdf | EFFECT OF SALVIA ABSCONDITIFLORA EXTRACT ON THE GENE EXPRESSIONS OF GSTO1 AND GSTZ1 IN MCF-7 AND MDA-MB-231 CELLS

PDF Source: znu00504000727.pdf | Polyphenols: food sources and bioavailability

Email: greg@swissmixit.com