Walnut: Publications and Research from SwissMixIt
Walnuts are the nut of any tree of the genus Juglans (Family Juglandaceae), particularly the Persian or English walnut, Juglans regia. A walnut is the edible seed of a drupe, and thus not a true botanical nut. It is commonly consumed as a nut. After full ripening for its edible seed when the shell has been discarded, it is used as a garnish or a snack. Nuts of the eastern black walnut (Juglans nigra) and butternuts (Juglans cinerea) are less commonly consumed. They are round, single-seeded stone fruits that grow from the walnut tree. They are a good source of healthful fats, protein, and fiber. They may enhance heart and bone health and help in weight management, among other benefits.
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Keywords: walnuts, collagen, anticancer, antioxidant, Alzheimer’s disease, amyloid beta protein, dementia, depression, oxidative stress, inflammation, mild cognitive impairment, nutrition, walnuts, randomized controlled trial, RCT, walnuts, males, mood, walnuts, omega-3 fatty acids, lipid metabolites, inflammation, Inflammatory Bowel Disease, ulcerative colitis, walnut, maturity, antioxidant properties, polyphenols, tocop
Summary of Abstracts:
Can Walnut Serve as a Magic Bullet for the Management of Non-Alcoholic Fatty Liver Disease Walnut contains many nutrients and bioactive components such as essential fatty acids, polyphenols, fiber, tocopherol, folate, minerals, and vegetable protein, and has therefore been regarded as a natural functional food. Walnut-enriched diets have been demonstrated to be useful for heart health, cancer prevention, and metabolic disorders owing to their anti-oxidative and anti-inflammatory properties as well as for the maintenance of a healthy metabolism and immune function. Walnut extracts, either phenolic or lipid, also demonstrated the health effects in animal and cultured cell studies. The beneficial effects of walnut consumption on non-alcoholic fatty liver disease, which is a hepatic manifestation of obesity, hyperlipidemia, type 2 diabetes mellitus, and metabolic syndrome with substantial hepatic accumulation of triglyceride, have been proposed because walnut and a walnut-containing diet can modulate the etiologic mechanism such as ameliorating systemic and hepatic dyslipidemia, reducing lipotoxicity and inflammation, enhancing immune function, and maintaining gut microbiota balance.
Three Decades of Research on Recombinant Collagens: Reinventing the Wheel or Developing New Biomedical Products Collagens provide the building blocks for diverse tissues and organs. Furthermore, these proteins act as signaling molecules that control cell behavior during organ development, growth, and repair. Their long half-life, mechanical strength, ability to assemble into fibrils and networks, biocompatibility, and abundance from readily available discarded animal tissues make collagens an attractive material in biomedicine, drug and food industries, and cosmetic products. Although many tests demonstrated that recombinant collagens perform as well as their native counterparts, the recombinant collagen technology has not yet been adopted by the biomedical, pharmaceutical, or food industry.
Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts (Juglans nigra) Using a High-Throughput Screening Approach Our recent studies have demonstrated multiple health-promoting benefits from black walnut kernels. These biological functions of black walnuts are likely associated with their bioactive constituents. Characterization of phenolic compounds found in black walnut could point out underexplored bioactive activities of black walnut extracts and promote the development of novel applications of black walnut and its byproducts. Our findings suggested that black walnut extracts possibly possess anticancer activities and supported that penta-O-galloyl-b-d-glucose could be a potential bioactive agent for the cosmetic and pharmaceutical industries.
Beneficial Effects of Walnuts on Cognition and Brain Health [ Walnuts help with brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation. ] Oxidative stress and neuroinflammation have important roles in the aging process, mild cognitive impairment (MCI), Alzheimer’s disease (AD), and other brain disorders. Amyloid beta protein (Ab) is the main component of amyloid plaques in the brains of people with AD. Several studies suggest that Ab increases the generation of free radicals in neurons, which leads to oxidative damage and cell death. Several animal and human studies have suggested that walnuts may also decrease the risk or progression of other brain disorders such as Parkinson’s disease, stroke, and depression, as well as of cardiovascular disease and type 2 diabetes. Together, these reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases.
Effects of Walnut Consumption on Mood in Young Adults—A Randomized Controlled Trial [ Walnuts improve mood. ] Walnuts contain a number of potentially neuroprotective compounds like vitamin E, folate, melatonin, several antioxidative polyphenols and significant amounts of w-3 fatty acids. In non-depressed healthy young males, walnuts seem to have the ability to improve mood.
Acute Consumption of Walnuts and Walnut Components Differentially Affect Postprandial Lipemia, Endothelial Function, Oxidative Stress, and Cholesterol Efflux in Humans with Mild Hypercholesterolemia Walnut consumption improves cardiovascular disease risk; however, to our knowledge, the contribution of individual walnut components has not been assessed. Cholesterol efflux increased by 3.3 percent following whole walnut consumption in J774 cells cultured with postprandial serum compared with fasting baseline (P = 0.02). Walnut oil favorably affected endothelial function and whole walnuts increased cholesterol efflux. These 2 novel mechanisms may explain in part the cardiovascular benefits of walnuts.
Dietary Walnut Supplementation Alters Mucosal Metabolite Profiles During DSS-Induced Colonic Ulceration [ Walnuts also contain a large number of phytochemicals, including phenolic antioxidants, and high levels of nutrients with beneficial properties to guard against a variety of diseases, including heart disease, diabetes, neurological disorders, inflammation and cancer. ] Walnuts contain a complex array of natural compounds and phytochemicals that exhibit a wide range of health benefits, including protection against inflammation and colon cancer. In colon tissue samples, walnuts caused a significant increase in the levels of S-adenosylhomocysteine (SAH) and betaine, important components of fatty acid b-oxidation. These metabolite changes may contribute in part to the observed protection against DSS-induced inflammatory tissue injury.
Role of Walnuts in Maintaining Brain Health with Age Increases in the incidence of chronic neurodegenerative disorders have become a societal concern, both in terms of decreased quality of life and increased financial burden. Lifestyle factors greatly affect the progression of cognitive decline, with high-risk behaviors including unhealthy diet, lack of exercise, smoking, and exposure to environmental toxins leading to enhanced oxidative stress and inflammation. English walnuts (Juglans regia L.) are rich in numerous phytochemicals, including high amounts of polyunsaturated fatty acids, and offer potential benefits to brain health. Polyphenolic compounds found in walnuts not only reduce the oxidant and inflammatory load on brain cells but also improve interneuronal signaling, increase neurogenesis, and enhance sequestration of insoluble toxic protein aggregates.
Effects of Walnuts on Serum Lipid Levels and Blood Pressure in Normal Men In a recent six-year follow-up study, we found that frequent consumption of nuts was associated with a reduced risk of ischemic heart disease. Mean blood-pressure values did not change during either dietary period. Incorporating moderate quantities of walnuts into the recommended cholesterol-lowering diet while maintaining the intake of total dietary fat and calories decreases serum levels of total cholesterol and favorably modifies the lipoprotein profile in normal men.
Impact of the Degree of Maturity of Walnuts (Juglans regia L.) and Their Variety on the Antioxidant Potential and the Content of Tocopherols and Polyphenols [ Polyphenolic content decreases with maturation of nuts. ] It was found that the content of dry matter and fat increased and the antioxidant properties decreased with the maturation of nuts. The polyphenolic content decreased with the maturation of nuts. The total content of tocopherols in the tested nuts increased with ripening and ranged from 1.76 mg/100g (Apollo VII) to 18.30 mg/100g (Resovia IX). It was found that the content of the nutrient increased as ripening increased. Ellagitannins represent a large group of polyphenolic compounds which has been extensively studied and which, as well as the ellagic acid itself, has recently attracted considerable attention due to their high antioxidant activity. Additionally, the ellagic acid has recently gained increasing interest due to beneficial properties and the health benefits associated with the intake of foods containing high ellagitannins levels in the prevention of cardiovascular diseases as well as neoplastic diseases. As shown in this study, the content of valuable bioactive substances (polyphenols, tocopherols) in walnuts significantly depends not only on their variety, but also on the degree of maturity. It was found that both, the antioxidant potential and the polyphenol content associated with it, decreased during the maturation of nuts. Unripe nuts are rich in ellagitannin, with strong antioxidant properties. In the polyphenol profile of nuts, 26 compounds that enhance their antioxidant properties have been identified. However, the content of tocopherols in nut oil increased as they matured. The high antioxidant potential and the content of bioactive compounds of unripe walnuts may contribute to the design of food products with pro-health qualities based on these raw materials.
Walnuts Have Potential for Cancer Prevention and Treatment [ Walnuts can slow the growth of cancer. ] Cancer may not be completely the result of novel or inherited genetic mutations but may in fact be a largely preventable disease. 1) the walnut containing diet inhibited the growth rate of human breast cancers implanted in nude mice by 80 percent; 2) the walnut containing diet reduced the number of mammary gland tumors by 60 percent in a transgenic mouse model; 3) the reduction in mammary gland tumors was greater with whole walnuts than with a diet containing the same amount of n-3 fatty acids, supporting the idea that multiple components in walnuts additively or synergistically contribute to cancer suppression; and 4) walnuts slowed the growth of prostate, colon, and renal cancers by antiproliferative and antiangiogenic mechanisms. Cell studies have aided in the identification of the active components in walnuts and of their mechanisms of action.
PDF Source: 0101-2061-cta-1678-457X20516.pdf | Comparative study of functional properties of eight walnut
PDF Source: 010SabateNEnglJMed1993.pdf | Effects of Walnuts on Serum Lipid Levels
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PDF Source: 2_14_Garbaczewska_GB.pdf | components of the extract from the leaves of walnut Juglans
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PDF Source: _20201019-swissmixit-pdf-search-library-methodology.pdf | SwissMixIt Methodology
PDF Source: A12.pdf | Supercritical fluid extraction of walnut kernel oil
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PDF Source: antioxidants-09-00976-v2.pdf | Anti-Amnesic Effect of Walnut via the Regulation of BBB
PDF Source: antioxidants-09-01272.pdf | Influence of the Location of Ascorbic Acid in Walnut Oil
PDF Source: applsci-10-06340.pdf | Walnut and Hazelnut Shells
PDF Source: applsci-10-08347-v2.pdf | Edible Oils Determination of Fatty Acids Profile
PDF Source: applsci-10-08695-v2.pdf | Attenuated Total Reflectance-Fourier Infrared Spectroscopy
PDF Source: applsci-11-00218-v2.pdf | Walnut vs Management of Non-Alcoholic Fatty Liver Disease
PDF Source: ATC5-Carpathian-walnut.pdf | Carpathian walnut (Juglans regia var. carpathian
PDF Source: bioengineering-07-00155.pdf | Recombinant Collagens
PDF Source: bioengineering-08-00003.pdf | Collagen Structure-Function Mapping Regenerative Medicine
PDF Source: biomedicines-08-00142-v2.pdf | RNA Sequencing-Based id of Ganglioside GD2-Positive cancer
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PDF Source: CWB-J0336B-Indusry-Overview_web-1.pdf | CALIFORNIA WALNUTS INDUSTRY OVERVIEW
PDF Source: CWB-J0349-Size-Color-Chart_web.pdf | CALIFORNIA WALNUTS SIZE COLOR
PDF Source: draft-assessment-report-juglans-regia-l-folium_en.pdf | Assessment report on Juglans regia L
PDF Source: energies-13-06359.pdf | Biochar Structure Resulting from Walnut
PDF Source: Extraction_of_phenolic_compounds_from_green_walnut.pdf | Extraction of phenolic compounds from green walnut
PDF Source: fnagi-08-00333.pdf | Walnuts and Healthy Aging Study (WAHA
PDF Source: FoodFunctionArticleFinal.pdf | Nuts, especially walnuts, have both antioxidant quantity
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PDF Source: foods-09-01207.pdf | Walnut Deterioration Using Kernel Oxidative Stability
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PDF Source: GLOBAL_EXTRACTION1.pdf | EXTRACTION COMPARISON OF OIL FROM BLACK WALNUT
PDF Source: H0144347.pdf | Aging and Nutrition: A Review Article
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PDF Source: ijms-21-07090.pdf | SARS-CoV-2 in Altering the RNA-Binding Protein and miRNA-Directed
PDF Source: ijms-21-09093-v2.pdf | Walnut Functional Genes and microRNA-Targets
PDF Source: jad-64-jad180361.pdf | Walnut vs Diet Reduces Oxidative Damage
PDF Source: juglone_508.pdf | SUMMARY OF DATA FOR CHEMICAL SELECTION Juglone
PDF Source: L1-chapter9nutbioactives.pdf | Nut Bioactives: Phytochemicals and Lipid-Based Components
PDF Source: molecules-23-02814.pdf | Optimization Phenolic Compounds Recovery from Walnut
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PDF Source: molecules-24-02936.pdf | Impact of the Degree of Maturity of Walnuts
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PDF Source: molecules-25-04516-v2.pdf | Profiling Anticancer and Antioxidant Activities of Phenolic Compounds Present in Black Walnuts
PDF Source: nanomaterials-10-02091-v2.pdf | Desalination vs Capacitive Deionization Nanoporous Carbon
PDF Source: nrs_2007_michler_001.pdf | Black Walnut USDA
PDF Source: nut1430788.pdf | Walnuts vs Postprandial Lipemia, Endothelial, Oxidative Stress
PDF Source: nut144555S.pdf | Walnuts Have Potential for Cancer Prevention
PDF Source: nutrients-08-00668.pdf | Effects of Walnut Consumption on Mood in Young Adults
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PDF Source: nutrients-10-01317.pdf | Effects of Long-Term Walnut Supplementation on Body Weight
PDF Source: nutrients-11-01118.pdf | Dietary Walnut Supplementation Alters Mucosal Metabolite
PDF Source: nutrients-12-00550.pdf | Beneficial Effects of Walnuts on Cognition and Brain Health
PDF Source: nutrients-12-00870-v2.pdf | Diet and Skin Aging From the Perspective of Food Nutrition
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PDF Source: polymers-12-01424-v2.pdf | Gelatin Films with Pecan Walnut and Shell Extract
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PDF Source: Role_of_Walnuts_in_Maintaining_Brain_Health_with_A.pdf | Role of Walnuts in Maintaining Brain Health
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